Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
نویسندگان
چکیده
BACKGROUND The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances. OBJECTIVES The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos. METHODS We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case-control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression. RESULTS After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters. CONCLUSIONS Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.
منابع مشابه
Oxidative stress indices in rats’ lung tissues following simultaneous exposure to noise and styrene
Background: Simultaneous exposure to noise and organic solvents such as styrene is an indispensable part of today’s industries. Numerous studies were done related to ototoxic effects of co-exposure to noise and styrene while some evidences showed the adverse effects of such exposure on other organs. In this study, we aimed to assess the subacute effects of combined exposure to noise and s...
متن کاملEffect of Exposure to a Mixture of Organic Solvents on Hearing Thresholds in Petrochemical Industry Workers
Introduction: Hearing loss is one of the most common occupational diseases. In most workplaces, workers are exposed to noise and solvents simultaneously, so the potential risk of hearing loss due to solvents may be attributed to noise. In this study we aimed to assess the effect of exposure to mixed aromatic solvents on hearing in the absence of exposure to hazardous noise. Materials and Met...
متن کاملMenstrual disturbances and hormonal changes in women workers exposed to a mixture of organic solvents in a pharmaceutical company
Background: Chemicals are among risk factors that can affect women's reproductive system. This study is aimed to investigate the association of occupational exposure to a mixture of organic solvents with menstruation disturbances and hormonal changes among female workers. Methods : Female workers of a pharmaceutical company were divided into three groups of non-exposed, low-exposed and high...
متن کاملبررسی ارتباط بین مواجهه شغلی با حلال آلی و خستگی کارگران یک کارخانه رنگ در شهر ساوه
Background and aims: Organic solvents are a group of chemical compounds widely used in various industries and so far the relationship between chronic exposure to them and some physical and neurological diseases has been proved. On the other hand, fatigue causes damage to the person, reduction in work efficiency and increase in occupational accidents. This study aimed...
متن کاملRisk of Cancer in Occupational Exposure to Radar Radiation: A Systematic Review
Background and aim: Microwave radiations are one of the most environmental workplace factors that exposed too many workers. In microwave spectrum, radar frequency with 1-300 GHz range have varied applications such as satellite, communications, military, Network, navigation, air-traffic Control, navigation, marine and weather. Uncontrolled occupational exposure to radar radiation caused to vari...
متن کامل